Sorafenib is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-ß and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor (IC50 = 6 nM), it has since been shown to have activity against many receptor tyrosine kinases involved in tumorigenesis and angiogenesis including FGFR-1, wt BRAF and V599E mutant BRAF, as well as members of the so-called "split kinase" family: VEGFR-2, VEGFR-3, PDGFR-ß, c-KIT, and Flt3. However, sorafenib is not active against erbB1, erbB2, ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-MET, c-yes, PKB, PKA, cdk1/cyclinB, PKC, and pim-1. In cellular mechanistic assays, sorafenib decreased basal phosphorylation of the ERK pathway in melanoma, breast, colon, and pancreatic tumor cell lines.

Eton Bioscience

为了满足研究团体对DNA测序的需求，EtonBioscience还提供了各种各样的定制服务和自己的产品系列。最初只为当地服务，现在我们为世界各地的研究机构服务。

Eton Bioscience Inc. is a privately held company located in beautiful San Diego, the heart of the biotech scene. Founded in 2003, we contribute to both life and science, providing the biological research communities of academia and industry with services which assist them in their ongoing experiments and investigations.

品牌	货号	名称	规格
Eton Bioscience	2400090101	AMP-Activated Protein Kinase a1 subunit	10ug
Eton Bioscience	2400090301	AMP-Activated Protein Kinase a2 subunit	30ug
Eton Bioscience	2400120101	Ataxia Telangiectasia and Rad3 related, FRAP-related protein	10ug